1. Re: Best route from Houston (TX) to Louisville (KY)
Unless there is something you must see in Shreveport, I would suggest this...
Houston to Natchez, Mississippi, then follow the Natchez Trace Parkway up to Memphis then to Nashville and on to Louisville. If you don't need to go to Memphis, follow the Natchez Trace Parkway all the way into Nashville.
Hope this helps!!
Source : https://www.tripadvisor.com/ShowTopic-g56003-i148-k2571246-Best_route_from_Houston_TX_to_Louisville_KY-Houston_Texas.html